Magnesium homeostasis. Etiopathogeny, clinical diagnosis and treatment of hypomagnesaemia. A case study

Magnesium is the fourth-most abundant cation in the human body and the second-most abundant intracellular cation after potassium. Magnesium is pivotal in the transfer, storage, and utilization of energy as it regulates and catalyzes more than 300 enzyme systems. Hypomagnesemia may thus result in a v...

Full description

Saved in:
Bibliographic Details
Published inNefrología Vol. 29; no. 6; pp. 518 - 524
Main Authors González, E Pérez, Santos, F, Coto, E
Format Journal Article
LanguageSpanish
Published Spain 2009
Subjects
Child
Female
Homeostasis
Humans
Magnesium - metabolism
Metabolic Diseases - diagnosis
Metabolic Diseases - etiology
Metabolic Diseases - therapy
Online AccessGet full text

Cover

More Information
Summary:Magnesium is the fourth-most abundant cation in the human body and the second-most abundant intracellular cation after potassium. Magnesium is pivotal in the transfer, storage, and utilization of energy as it regulates and catalyzes more than 300 enzyme systems. Hypomagnesemia may thus result in a variety of metabolic abnormalities and clinical consequences. It results from an imbalance between gastrointestinal absorption and renal excretion of magnesium. The main consequence related directly to hypomagnesemia is cardiovascular arrhythmias secondary to hipokaliemia and if this is not recognized and treated it may be fatal. In this article we review the hypomagnesemic disorders in children with emphasis on the molecular mechanisms responsible for abnormalities in magnesium homeostasis, differential diagnosis and appropriate therapy, and we describe the clinical and biochemical manifestations as well as the genetic defect in a family with Gitelman syndrome.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Review-3
content type line 23
ObjectType-Case Study-5
ObjectType-Feature-1
ObjectType-Report-4
ISSN:0211-6995
DOI:10.3265/Nefrologia.2009.29.6.5534.en.full