A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unal...

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Published inChemical communications (Cambridge, England) Vol. 60; no. 81; pp. 11516 - 11519
Main Authors Hu, Yuwei, Chen, Feng, Lu, Hongfang, Tan, Susi, Ke, Yujie, Loh, Wei Wei, Soh, Eugene Jia Hao, Taniya, Agarwal, Tabaglio, Tommaso, Wee, Dave Keng Boon, Ying, Jackie Y
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 08.10.2024
Subjects
Disintegration
DNA - chemistry
Hydrogen-Ion Concentration
Nanogels - chemistry
Oligonucleotides - chemistry
Polyethylene Glycols - chemistry
Polyethyleneimine - chemistry
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Summary:A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc01942c