PROSPECTIVE STUDY ON THE DEVELOPMENT OF ALLOIMMUNE THROMBOCYTOPENIA IN NEONATES BORN TO MOTHERS WITH ANTI-HPA-4B

• Published in: Journal of the Japan Society of Blood Transfusion Vol. 46; no. 5; pp. 463 - 466
• Main Authors: Yosimatu, Nobuhiro, Ohsugi, Kazuo, Ishijima, Ayako, Takasaki, Katsunori, Fujimori, Keiya, Enomoto, Takayuki, Azuma, Tatsuro, Sato, Akira, Yamaguchi, Osamu, Tohyama, Yuriko, Hando, Keiichi, Imamura, Shinya, Kin, Shogo, Nemoto, Kimio, Morita, Shoji, Sugafuji, Mitsuru, Yamaguchi, Tomiko, Yosida, Takao, Takeuchi, Chikako, Ohto, Hitoshi, Sato, Eiji
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Transfusion Medicine and Cell Therapy 2000
• Subjects: alloimmune; HPA-4b; neonatal alloimmune thrombocytopenia; newborn; pregnancy
• ISSN: 0546-1448; 1883-8383
• DOI: 10.3925/jjtc1958.46.463

Among the 21, 354 pregnant women studied, anti-HPA-4b was detected in 39 (0.18%), and 6 neonates developed neonatal alloimmune thrombocytopenia (NAIT; platelet count<15×104/μl). Platelet count at delivery was significantly different between neonates compatible (27.0×104/μl) and incompatible (15.3×104/μl, p<0.05) with maternal anti-HPA-4b. However, no significant difference between maternal anti-HPA-4b titer and the platelet count of incompatible neonates was observed. High titer (>64) of anti-HPA-4b, however, was associated with a higher risk of NAIT. In addition, normalization of platelet count (>15×104/μl) was delayed in babies from mothers with high antibody titer (>64) compared with babies from women with low antibody titer (≤64).