Clinics in diagnostic imaging (193)

A 68-year-old man presented with a three-week history of rapidly progressive dementia, gait ataxia and myoclonus. Subsequent electroencephalography showed periodic sharp wave complexes, and cerebrospinal fluid assay revealed the presence of a 14-3-3 protein. A probable diagnosis of sporadic Creutzfe...

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Bibliographic Details
Published inSingapore medical journal Vol. 59; no. 12; pp. 634 - 641
Main Authors Li, JSY, Lim, KC, Lim, WEH, Chen, RC
Format Journal Article
LanguageEnglish
Published Singapore Singapore Medical Association 01.12.2018
Subjects
Medical Education
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Summary:A 68-year-old man presented with a three-week history of rapidly progressive dementia, gait ataxia and myoclonus. Subsequent electroencephalography showed periodic sharp wave complexes, and cerebrospinal fluid assay revealed the presence of a 14-3-3 protein. A probable diagnosis of sporadic Creutzfeldt-Jakob disease was made, which was further supported by magnetic resonance (MR) imaging of the brain showing asymmetric signal abnormality in the cerebral cortices and basal ganglia. The aetiology, clinical features, diagnostic criteria, various MR imaging patterns and radiologic differential diagnosis of sporadic Creutzfeldt-Jakob disease are discussed in this article.
ISSN:0037-5675
DOI:10.11622/smedj.2018146