Indicators of metabolic syndrome in normotensive normoglycemic asthmatic patients

• Published in: Journal of clinical and translational research Vol. 6; no. 1; pp. 27 - 35
• Main Authors: Sourg, Hanadi Abdelgadir Ahmed, Ahmed, Adil Ballal Mohammed, Elhakeem, Ramaze Farouke, Lutfi, Mohamed Faisal
• Format: Journal Article
• Language: English
• Published: Singapore Whioce Publishing Pte. Ltd 16.07.2020
• Subjects: Original; metabolic syndrome; bronchial asthma; diabetes mellitus; hypertension; insulin resistance
• ISSN: 2424-810X; 2382-6533; 2424-810X
• DOI: 10.18053/jctres.06.202001.005

Pathophysiology of hypertension and bronchial asthma (BA) shares many similarities, especially those related to the metabolic syndrome (MS). In this study, the indicators of the MS were evaluated in normoglycemic normotensive asthmatic patients to clarify if the components of the MS can still interact to increase the risk of BA, provided that blood pressure and glucose level are kept within the normal physiological ranges. Body mass index (BMI), waist circumference (WC), mean arterial blood pressure (MABP), fasting blood glucose (FBG) and fasting blood insulin (FBI) levels, the quantitative insulin sensitivity check index (QUICKI), serum lipid profile, and spirometric measurements were all compared between 120 asthmatic patients and 59 non-asthmatic subjects. Cigarette smoking, pregnancy, age below 20 years or above 40 years, diabetes mellitus and hypertension, and other chronic diseases were excluded from all studied groups. Asthmatic patients demonstrated higher WC (median [25 -75 interquartile]=88.50 [78.00-101.75], FBI [19.98 (11.12-40.14)], and triglyceride (TG) level [109.5 (76.50-134.0)]) compared with non-asthmatic subjects (81.00 [72.00-92.00], 13.78 [8.84-30.24], and 89.00 [64.25-104], <0.05). QUICKI and MABP were lower in asthmatic patients (0.310 [0.283-0.338] and 86.66 [83.33-93.33]) compared with non-asthmatic subjects (0.320 [0.297-0.353] and 93.33 [83.33-93.33]), ( <0.05). BMI, FBG, low-density lipoprotein, high-density lipoprotein, and total cholesterol levels were comparable in the studied groups. The present finding gives further evidence for higher WC, FBI, TG level, and insulin resistance in normotensive, normoglycemic asthmatic patients compared to healthy controls. The findings of this study suggested that abdominal obesity, hypertriglyceridemia, hyperinsulinemia, and insulin resistance may still be interacting and hence increase the risk of BA in normotensive, normoglycemic subjects.