Study on cellular immunity in chronic hemodialysis patients and continuous ambulatory peritoneal dialysis patients

• Published in: Journal of Japanese Society for Dialysis Therapy Vol. 19; no. 12; pp. 1093 - 1098
• Main Authors: Kubota, Kazuo, Kaneko, Yoshiteru, Motomiya, Yoshihiro, Tsumatani, Kenichi, Moriya, Akira, Kyuma, Tomoko, Okajima, Eigoro, Komada, Sadao, Maruyama, Yoshio, Hirao, Yoshihiko, Ohara, Souichi, Aoyama, Hideo
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society for Dialysis Therapy 1986
• Subjects: CAPD
• ISSN: 0911-5889; 1884-6211
• DOI: 10.4009/jsdt1985.19.1093

Cellular immunity in hemodialysis patients and continuous ambulatory peritoneal dialysis (CAPD) patients was studied with regard to natural killer cell activity (NK activity) and to the antibody-dependent, cell-mediated cytotoxic activity (ADCC activity) of killer cells. To investigate the effect of hemodialysis, the NK and ADCC activities were determined before and after hemodialysis. Twenty hemodialysis patients (16 male, 4 female) and 7 CAPD patients (5 male, 2 female) were included in this study. The hemodialysis patients' ages ranged from 13 to 79 years (mean=50.2) and the CAPD patients' ages ranged from 27 to 67 years (mean=46.7). Six healthy subjects were also studied to compare the results. There was no relation between NK activity and duration and age in either hemodialysis patients or CAPD patients. And there was no relation between ADCC activity and duration and age in hemodialysis patients and CAPD patients. The NK activities in hemodialysis patients were 19.6%±6.5% and were significantly decreased compared with 36.4%±14.8% in normal subjects (P<0.001). The ADCC activities in hemodialysis patients were 54.7%±10.4% and were also significantly decreased compared with 71.4%±4.2% in normal subjects (p<0.01). No differences with regard to NK activity and ADCC activity were observed between hemodialysis patients and CAPD patients, or between normal subjects and CAPD patients. In 5 patients there was no difference in NK activity before and after hemodialysis, but the ADCC activity was 65.2%±2.9% before hemodialysis and 52.4%±5.6% after hemodialysis-a significant difference (p<0.01). The present study comfirmed that hemodialysis is not able to improve NK activity, and it showed a deterioration of the ADCC activity with hemodialysis.