Preliminary Study of Scandium-46 Labeled Composite (Hydroxyapatite-Chitosan-Collagen) Biodistribution in Rats Bone Implant Model

Research related to bone fractures is currently focused on accelerating healing time with fewer complications. In some cases related to biological and mechanical factors that interfere with the healing process, it will take a longer time to heal. Hydroxyapatite (HA) is a promising material used as a...

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Bibliographic Details
Published inJournal of physics. Conference series Vol. 1436; no. 1; pp. 12052 - 12057
Main Authors Kurniawan, A, Febrian, M B, Iswahyudi, Daruwati, I, Sugiharti, R J, Setiadi, Y, Darwis, D, Abbas, B, Lukitowati, F, Warastuti, Y
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.01.2020
Subjects
Biodistribution
Biomedical materials
Chitosan
Collagen
Femur
Fractures
Healing
Hydroxyapatite
In vivo methods and tests
Organs
Physics
Radioactivity
Radioisotopes
Scandium
Scandium oxides
Transplants & implants
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Summary:Research related to bone fractures is currently focused on accelerating healing time with fewer complications. In some cases related to biological and mechanical factors that interfere with the healing process, it will take a longer time to heal. Hydroxyapatite (HA) is a promising material used as a scaffold for bone implants with various advantages. The in vivo biodistribution of Sc-46 labeled composite (HA-Chitosan-Collagen) remains unclear. In this research, Scandium-46 was prepared as a non-carrier free radioisotope solution by irradiating 100 mg Sc2O3 target in TRIGA 2000 Reactor Bandung. In vivo experiment was performed on Sprague Dawley rats weighing approximately 250 g. Rats bone implant model was divided into two groups with n = 3 per time point. The Sc-46 labeled composite (HA-Chitosan-Collagen) have implanted to rats femur 10 mg with radioactivity 10 μCi. Rats were euthanized using accepted protocol and all organs were counted for radioactivity using Wipe Test Counter with NaI(Tl) detector. The percent of radioactivity measured per gram of tissue weight (%ID/g). Biodistribution results showed that Sc-46 labeled composite (HA-Chitosan-Collagen) using the bone-implant method were significantly different compared with the normal bone for 1, 3, and 8 days of the time interval with p<0.05. These observations suggest that Composite (HA-Chitosan-Collagen) is available for bone implants and remains at the implant site until bone recovery.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1436/1/012052