120 Hypocholesterolemic Effect of a 10% Fish Oil Iv Lipid Emulsion in Preterm Infants

• Published in: Pediatric research Vol. 68; no. Suppl 1; pp. 63 - 64
• Main Authors: D'Ascenzo, R, Angelini, L, D'Egidio, S, Bellagamba, M P, Bartoli, A, Burattini, I, Cogo, P E, Carnielli, V P
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2010
• Subjects: Medicine & Public Health; oral-abstract; Pediatric Surgery; Pediatrics
• ISSN: 0031-3998; 1530-0447
• DOI: 10.1203/00006450-201011001-00120

Background: New lipid emulsions containing fish oil (FO) are recently became available, but there are no informations on their use in preterm infants. Objective: To compare in preterms a 10% FO/50%MCT/40% soy emulsion (FMS) with a 50% MCT/50% soy emulsion (MS). Design/Methods: Forty seven premature infants were randomized to receive FMS (n=23, GA 202 ± 17 days, BW 1017 ± 203 g) or MS (n=24, GA 195 ± 10 days, BW 1009 ± 211 g). The IV lipid dose was increased to 2,5 g•kg −1 •d −1 within 7 days. All infants were on minimal enteral feeding from birth to d7; they reached full feed on d17. Plasma lipids were determined in cord blood and at d7 and D14 by gas chromatography and mass spectrometry. Routine biochemistry was also performed as part of standard practice. Data were compared using a t-test (p< 0.05). Results: Plasma free cholesterol (FC) and cholesterol esters (CE) are reported below. Table Table ?emptypara? Conclusion: The FMS emulsion was associated with a marked reduction of plasma cholesterol. If fish oil reduces cholesterol byosintesis or enhances its clearance is unknown in preterm infants. The clinical benefits or lack of benefits of these findings should be assessed in cardiovascular and neurodevelopmental follow up studies.