Lymphocyte subpopulation in primary lung cancer

To determine whether impaired cellular immune responsiveness in lung cancer patients is related to a reduction in the number of T lymphocytes, circulating levels of T-rosette-forming lymphocytes were measured in 48 cases with primary lung cancer and compared to levels in 94 age-matched healthy subje...

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Bibliographic Details
Published inOncology Vol. 36; no. 4; p. 176
Main Authors Alsabti, E A, Safo, M H, Shaheen, A
Format Journal Article
LanguageEnglish
Published Switzerland 1979
Subjects
Adenocarcinoma - immunology
Adenocarcinoma, Bronchiolo-Alveolar - immunology
Aged
B-Lymphocytes - immunology
Carcinoma, Squamous Cell - immunology
Female
Humans
Immunity, Cellular
Immunoglobulins - analysis
In Vitro Techniques
Lung Neoplasms - immunology
Male
Middle Aged
Rosette Formation
Skin Tests
T-Lymphocytes - immunology
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Summary:To determine whether impaired cellular immune responsiveness in lung cancer patients is related to a reduction in the number of T lymphocytes, circulating levels of T-rosette-forming lymphocytes were measured in 48 cases with primary lung cancer and compared to levels in 94 age-matched healthy subjects. The results show that T lymphocytes levels are significantly reduced in lung cancer patients. A possible consequence of reduced numbers of circulating T lymphocytes would be a diminution in tumor-inhibiting (T-cell) influences and a corresponding relative enhancement of blocking (B-cell) influences, a circumstance which would favor tumor proliferation.
ISSN:0030-2414
DOI:10.1159/000225335