Basophil histamine release and lymphocyte proliferation tests in latex contact urticaria. In vitro tests in latex contact urticaria

Basophil histamine release and lymphocyte proliferation tests were examined with latex allergen prepared from surgical gloves in 15 patients with latex contact urticaria. The basophil histamine release test (BHRT) yielded positive results in 13/14 (93%) patients, whereas commercial latex RAST was po...

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Bibliographic Details
Published inAllergy (Copenhagen) Vol. 44; no. 3; p. 181
Main Authors Turjanmaa, K, Räsänen, L, Lehto, M, Mäkinen-Kiljunen, S, Reunala, T
Format Journal Article
LanguageEnglish
Published Denmark 01.04.1989
Subjects
Adult
Basophils - metabolism
Female
Histamine Release
Humans
Latex - adverse effects
Lymphocyte Activation
Male
Radioallergosorbent Test - methods
Urticaria - chemically induced
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Summary:Basophil histamine release and lymphocyte proliferation tests were examined with latex allergen prepared from surgical gloves in 15 patients with latex contact urticaria. The basophil histamine release test (BHRT) yielded positive results in 13/14 (93%) patients, whereas commercial latex RAST was positive in only 9/15 (60%) patients. Lymphocyte proliferation test (LPT) was positive in 3/15 (20%) patients, suggesting that cell-mediated immune reactions may also occur in latex allergy. However, patch tests to latex were negative and neither were epidermal Langerhans cells able to present latex antigen to T lymphocytes in vitro.
ISSN:0105-4538
DOI:10.1111/j.1398-9995.1989.tb02259.x