Predictive factors for intrahepatic distant recurrence of hepatocellular carcinoma after radiofrequency ablation for primary tumors

• Published in: Kanzo Vol. 47; no. 4; pp. 209 - 216
• Main Authors: Hikita, Hayato, Tanaka, Yoshio, Shigekawa, Minoru, Mukai, Kaori, Nakamura, Keiko, Song, Changho, Tatsumi, Osamu, Inoue, Yuko, Sasakawa, Akira, Nakanishi, Fumihiko, Masuda, Eiji, Hijioka, Taizo
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Hepatology 2006
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.47.209

We studied 56 patients with primary hepatocellular carcinoma (HCC) treated with radiofrequency ablation (RFA) in our hospital to clarify the predictive factors for intrahepatic distant recurrence. The observation period was 16.4 months. Cumulative rate of recurrence was 12.0% in a year and 53.5% in 3 years. Multivariate analysis revealed that multinodular HCC (odds ratio 4.78, p=0.01) and platelet count <10.0×104/μl (odds ratio 5.25, p<0.01) were considered to be useful predictive factors for recurrence. These recurrence rate and factors after RFA were similar to those after surgical resection. Therefore, patients showed uninodular HCC and whose platelet count was 10.0×104/μl and over before treatment might not be treated with RFA, but surgical resection if possible. However, considering remnant liver function and recurrence rate, we think patients either showed multinodular HCC or whose platelet count was less than 10.0×104/μl before treatment should be treated with RFA if possible.