Synthesis of new 2-substituted 3-(tri(di)fluoromethyl)-quinoxalines from 3-(trifluoromethyl)quinoxalin-2(1H)-oneand 3-(tri(di)fluoromethyl)quinoxaline-2-carboxylic acids

Starting from 3-(trifluoromethyl)quinoxalin-2(1 H )-one, a wide range of new 2-substituted 3-(trifluoromethyl)quinoxalines were obtained, including amino, bromo, chloro, hydrazino, phenyl, α-furyl, formyl, methylsulfanyl, and methylsulfonyl derivatives. 3-(Tri(di)-fluoromethyl)quinoxaline-2-carboxyl...

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Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 51; no. 3; pp. 259 - 268
Main Authors Didenko, Andrey V., Vorobiev, Mikhail V., Sevenard, Dmitri V., Sosnovskikh, Vyacheslav Ya
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2015
Subjects
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
quinoxalin-2
2-substituted 3-(tri(di)fluoromethyl)-quinoxalines
quinoxaline-2-carboxylic acid
thione
quinoxaline-2
one
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Summary:Starting from 3-(trifluoromethyl)quinoxalin-2(1 H )-one, a wide range of new 2-substituted 3-(trifluoromethyl)quinoxalines were obtained, including amino, bromo, chloro, hydrazino, phenyl, α-furyl, formyl, methylsulfanyl, and methylsulfonyl derivatives. 3-(Tri(di)-fluoromethyl)quinoxaline-2-carboxylic acids were obtained for the first time and used for the synthesis of 2-amino-3-(tri(di)-fluoromethyl)quinoxalines and 2-(2-aminothiazol-4-yl)-3-(trifluoromethyl)quinoxaline.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-015-1694-5