Fibroblast growth factor-23, vitamin D and mineral metabolism in renal transplant recipients

• Published in: Indian journal of transplantation Vol. 10; no. 1; pp. 1 - 4
• Main Authors: Mehrotra, Sonia, Sharma, Raj K., Patel, Manas R., Prasad, Narayan, Gupta, Amit, Bhadauria, Dharmendra S., Kaul, Anupama
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2016; Wolters Kluwer Medknow Publications
• Subjects: Fibroblast growth factor; Immune function; Renal transplant recipients; Vitamin D and mineral metabolism; Fibroblast growth factor; Vitamin D and mineral metabolism; Immune function; Renal transplant recipients
• ISSN: 2212-0017; 2212-0025
• DOI: 10.1016/j.ijt.2016.03.004

In CKD patients various disturbances in vitamin D metabolism in addition to their classical effects on mineral bone disorder (MBD), also can have important effects on innate or adaptive immunity through various signaling pathways. Vitamin D deficiency could be a factor for triggering rejection, chronic allograft nephropathy and infections in post-transplant period. Patients with CKD are known to be both 25-hydroxyvitamin D (25OHD3) and 1,25-dihydroxyvitamin D (1,25[OH]2D3) deficient. Several observational studies have shown that treatment of ESRD patients with vitamin D analogues is associated with improved survival. 1,25(OH)2-D3 has long been recognized to have an immune regulatory function besides its role in calcium homeostasis. There is evidence in literature that indicates that 1,25(OH)2-D3 could have an important role in the regulation of immune function. This could have important clinical implications. Transplant physicians and surgeons should understand that vitamin D has a variety of immunological actions which can have important effect on patient and graft survival after transplantation.