Synthesis and preliminary scintigraphic evaluation of in vivo distribution of 11C-hydroxyurea/isohydroxyurea and 11C-Cyanate

H 11CN, produced directly from proton bombardment of 99% N 2−1% H 2 [ 14 N(p, α) 11 C] , was oxidized by KMnO 4 to 11C-cyanate which was added to hydroxylamine at −5 to 0°C to yield a mixture of hydroxyurea and isohydroxyurea. Scintigraphic evaluation of in vivo distribution in a dog following admin...

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Published inThe International journal of applied radiation and isotopes Vol. 29; no. 7; pp. 443 - 447
Main Authors Winstead, Meldrum B., Chern, Chuen-ing, Lin, Tz-Hong, Khentigan, Archie, Lamb, James F., Winchell, H.S.
Format Journal Article
LanguageEnglish
Published United States Elsevier B.V 01.07.1978
Subjects
Animals
Carbon Radioisotopes
Cyanates - metabolism
Dogs
Female
Hydrogen Cyanide - metabolism
Hydroxyurea - metabolism
Radionuclide Imaging
Rats
Time Factors
Tissue Distribution
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Summary:H 11CN, produced directly from proton bombardment of 99% N 2−1% H 2 [ 14 N(p, α) 11 C] , was oxidized by KMnO 4 to 11C-cyanate which was added to hydroxylamine at −5 to 0°C to yield a mixture of hydroxyurea and isohydroxyurea. Scintigraphic evaluation of in vivo distribution in a dog following administration of KO 11CN showed diffuse whole-body distribution, apparently including brain, with greater activity seen in regions of the heart, liver, and kidneys. Similar evaluation of a dog given 11C-hydroxyurea/isohydroxyurea showed early localization of activity in the region of the heart which appeared to be due to activity in the myocardium. However, tissue activity measured in rats after administration of this material failed to demonstrate concentration in the myocardium.
ISSN:0020-708X
DOI:10.1016/0020-708X(78)90081-9