A case of recurrent hepatitis C after liver transplantation associated with pulmonary tuberculosis and mediastinal tuberculous lymphadenitis

• Published in: Kanzo Vol. 50; no. 9; pp. 520 - 526
• Main Authors: Kinoshita, Akiyoshi, Itagaki, Munenori, Aoki, Yoshihiko, Matsudaira, Hiroshi, Ishiguro, Haruya, Nikami, Toshiki, Uetake, Shinichiro, Takikawa, Shingo, Searashi, Yasuyuki, Koike, Kazuhiko, Hokari, Atsushi, Ishikawa, Tomohisa, Takahashi, Hiroki, Zeniya, Mikio, Tajiri, Hisao, Odaka, Makoto
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Hepatology 2009
• Subjects: interferon; liver transplantation; mediastinal tuberculous lymphadenitis; pulmonary tuberculosis; recurrent hepatitis C
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.50.520

A 50-year-old man underwent orthotopic liver transplantation in June 2006 for decompensated cirrhosis due to hepatitis C virus infection. In March 2007 he was diagnosed with recurrent hepatitis C and he was given interferon α2b and ribavirin. 17 months after interferon treatment, serum HCV-RNA was negative. At the same period, a CT scan of the chest showed multiple mediastinal lymphadenopathy, and a pale opacity in the left upper lobe. Thoracoscopic biopsy of mediastinal lymph node confirmed mediastinal tuberculous lymphadenitis. Then he was treated with combined therapy with 4 anti-tuberculous drugs (RFP, INH, EB, and PZA). Until now he has been given interferon α2b and ribavirin with anti-tuberculous therapy. Although mediastinal tuberculous lymphadenitis after liver transplantation is rare, we must recognize the disease as a complication after liver transplantation.