Signaling through Ca 2+ Microdomains from Store-Operated CRAC Channels

Calcium (Ca ) ion microdomains are subcellular regions of high Ca concentration that develop rapidly near open Ca channels in the plasma membrane or internal stores and generate local regions of high Ca concentration. These microdomains are remarkably versatile in that they activate a range of respo...

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Bibliographic Details
Published inCold Spring Harbor perspectives in biology Vol. 12; no. 7; p. a035097
Main Authors Barak, Pradeep, Parekh, Anant B
Format Journal Article
LanguageEnglish
Published United States 01.07.2020
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Summary:Calcium (Ca ) ion microdomains are subcellular regions of high Ca concentration that develop rapidly near open Ca channels in the plasma membrane or internal stores and generate local regions of high Ca concentration. These microdomains are remarkably versatile in that they activate a range of responses that differ enormously in both their temporal and spatial profile. In this review, we describe how Ca microdomains generated by store-operated calcium channels, a widespread and conserved Ca entry pathway, stimulate different signaling pathways, and how the spatial extent of a Ca microdomain can be influenced by Ca ATPase pumps.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a035097