High dose chemotherapy followed by autologous bone marrow transplantation (ABMT) and daily infusion of granulocyte colony stimulating factor (G-CSF) for malignant tumors in adults
Fourteen adult patients with resistant malignant tumors (3 with malignant lymphoma, 3 with acute lymphocytic leukemia, 5 with recurrent breast cancer and 3 with germ cell tumor) received high dose chemotherapy followed by autologous bone marrow transplantation (ABMT) and daily infusion of granulocyt...
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| Published in | Journal of the Japan Society of the Reticuloendothelial System Vol. 31; no. 5; pp. 479 - 486 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japanese Society for Lymphoreticular Tissue Research
1991
|
| Online Access | Get full text |
| ISSN | 0386-9725 1883-6801 |
| DOI | 10.3960/jslrt1961.31.479 |
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| Abstract | Fourteen adult patients with resistant malignant tumors (3 with malignant lymphoma, 3 with acute lymphocytic leukemia, 5 with recurrent breast cancer and 3 with germ cell tumor) received high dose chemotherapy followed by autologous bone marrow transplantation (ABMT) and daily infusion of granulocyte colony stimulating factor (G-CSF). All the 14 patients showed bone marrow engraftment. Median neutrophilic recovery over 500/cmm was 12 days after ABMT, and no life-threatening infection occurred during neutropenic period. As compared with literature controls of high dose chemotherapy followed by ABMT not using G-CSF in Western countries, our results showed earlier recovery of neutrophils. It is suggested that G-CSF may shorten neutropenic period after ABMT. Non-hematologic regimen-related toxicities were under control. No therapy-related death was observed. Disease oriented, multicenter phase II studies of high dose chemotherapy followed by ABMT and daily infusion of G-CSF are ongoing. |
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| AbstractList | Fourteen adult patients with resistant malignant tumors (3 with malignant lymphoma, 3 with acute lymphocytic leukemia, 5 with recurrent breast cancer and 3 with germ cell tumor) received high dose chemotherapy followed by autologous bone marrow transplantation (ABMT) and daily infusion of granulocyte colony stimulating factor (G-CSF). All the 14 patients showed bone marrow engraftment. Median neutrophilic recovery over 500/cmm was 12 days after ABMT, and no life-threatening infection occurred during neutropenic period. As compared with literature controls of high dose chemotherapy followed by ABMT not using G-CSF in Western countries, our results showed earlier recovery of neutrophils. It is suggested that G-CSF may shorten neutropenic period after ABMT. Non-hematologic regimen-related toxicities were under control. No therapy-related death was observed. Disease oriented, multicenter phase II studies of high dose chemotherapy followed by ABMT and daily infusion of G-CSF are ongoing. |
| Author | Tamayose, Kenji Takeyama, Kunihiko Narabayashi, Masaru Kohno, Akio Tobinai, Kensei Hayashi, Masaki Shimoyama, Masanori |
| Author_xml | – sequence: 1 fullname: Kohno, Akio organization: Hematology-Oncology, National Cancer Center Hospital – sequence: 1 fullname: Tamayose, Kenji organization: Medical Oncology Division, National Cancer Center Hospital – sequence: 1 fullname: Shimoyama, Masanori organization: Hematology-Oncology, National Cancer Center Hospital – sequence: 1 fullname: Hayashi, Masaki organization: Medical Oncology Division, National Cancer Center Hospital – sequence: 1 fullname: Tobinai, Kensei organization: Hematology-Oncology, National Cancer Center Hospital – sequence: 1 fullname: Takeyama, Kunihiko organization: Medical Oncology Division, National Cancer Center Hospital – sequence: 1 fullname: Narabayashi, Masaru organization: Medical Oncology Division, National Cancer Center Hospital |
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| References | 9) Beelen DW, Quabeck K, Graeven U, Sayer HG, Mahmoud HK and Schaefer UW: Acute toxicity and first clinical results of intensive postinduction therapy using a modified busulfan and cyclophosphamide regimen with autologous bone marrow rescue in first remission of acute myeloid leukemia. Blood 74: 1507-1516 1989 7) Eder JP, Antman K, Elias A, Shea TC, Teicher B, Henner WD, Schryber SM, Holden S, Finberg R, Chritchlow J, Flaherty M, Mick R, Schnipper LE and Frei III R: Cyclophosphamide and thiotepa with autologous bone marrow transplantation in patients with solid tumors. J Natl Cancer Inst 80: 1221-1226 1988 2) Goldstone AH and Khwaja A: The role of haematopoietic growth factors in bone marrow transplantaion. Leukemia Res 14: 721-729 1990 6) Tutschka PJ, Copelan EA and Klein JP: Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen. Blood 70: 1382-1388 1987 4) Kuga T, Komatsu Y, Yamasaki M, Sekine S, Miyaji H, Nishi T, Sato M, Yokoo Y, Asano M, Okabe M, Morimoto M and Itoh S: Mutagenesis of human granulocyte colony stimulating factor. Biochem Biophys Res Communi 159: 103-111 1989 8) Williams SF, Bitran JD, Kaminer L, Westbrook C, Jacobs R, Ashenhurst J, Robin E, Purl S, Beschorner J, Schoeder C and Golomb HM: A phase I-II study of bialkylator chemotherapy, high-dose thiotepa, and cyclophosphamide with autologous bone marrow reinfusion in patients with advanced cancer. J Clin Oncol 5: 260-265 1987 1) Armitage JO: Bone marrow transplantation in the treatment of patients with lymphoma. Blood 73: 1749-1758 1989 3) Souza LM, Boone TC, Gabrilove J, Lai PH, Zsebo KM, Murdock DC, Chazin VR, Bruszewski J, Lu H, Chen KK, Barendt J, Platzer E, Moore MAS, Mertelsmann R and Welte K: Recombinant human granulocyte colony-stimulating factor: Effects on normal and leukemic myeloid cells. Science 232: 61-65 1986 5) Hayashi M, Takeyama K, Takayama J, Ohira M, Tobinai K and Shimoyama M: Severe herpes simplex virus hepatitis following autologous bone marrow transplantation: Successful treatment with high dose intravenous acyclovir. Jpn J Clin Oncol 21: 372-376 1991 |
| References_xml | – reference: 6) Tutschka PJ, Copelan EA and Klein JP: Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen. Blood 70: 1382-1388 1987 – reference: 7) Eder JP, Antman K, Elias A, Shea TC, Teicher B, Henner WD, Schryber SM, Holden S, Finberg R, Chritchlow J, Flaherty M, Mick R, Schnipper LE and Frei III R: Cyclophosphamide and thiotepa with autologous bone marrow transplantation in patients with solid tumors. J Natl Cancer Inst 80: 1221-1226 1988 – reference: 4) Kuga T, Komatsu Y, Yamasaki M, Sekine S, Miyaji H, Nishi T, Sato M, Yokoo Y, Asano M, Okabe M, Morimoto M and Itoh S: Mutagenesis of human granulocyte colony stimulating factor. Biochem Biophys Res Communi 159: 103-111 1989 – reference: 5) Hayashi M, Takeyama K, Takayama J, Ohira M, Tobinai K and Shimoyama M: Severe herpes simplex virus hepatitis following autologous bone marrow transplantation: Successful treatment with high dose intravenous acyclovir. Jpn J Clin Oncol 21: 372-376 1991 – reference: 1) Armitage JO: Bone marrow transplantation in the treatment of patients with lymphoma. Blood 73: 1749-1758 1989 – reference: 2) Goldstone AH and Khwaja A: The role of haematopoietic growth factors in bone marrow transplantaion. Leukemia Res 14: 721-729 1990 – reference: 8) Williams SF, Bitran JD, Kaminer L, Westbrook C, Jacobs R, Ashenhurst J, Robin E, Purl S, Beschorner J, Schoeder C and Golomb HM: A phase I-II study of bialkylator chemotherapy, high-dose thiotepa, and cyclophosphamide with autologous bone marrow reinfusion in patients with advanced cancer. J Clin Oncol 5: 260-265 1987 – reference: 9) Beelen DW, Quabeck K, Graeven U, Sayer HG, Mahmoud HK and Schaefer UW: Acute toxicity and first clinical results of intensive postinduction therapy using a modified busulfan and cyclophosphamide regimen with autologous bone marrow rescue in first remission of acute myeloid leukemia. Blood 74: 1507-1516 1989 – reference: 3) Souza LM, Boone TC, Gabrilove J, Lai PH, Zsebo KM, Murdock DC, Chazin VR, Bruszewski J, Lu H, Chen KK, Barendt J, Platzer E, Moore MAS, Mertelsmann R and Welte K: Recombinant human granulocyte colony-stimulating factor: Effects on normal and leukemic myeloid cells. Science 232: 61-65 1986 |
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| Title | High dose chemotherapy followed by autologous bone marrow transplantation (ABMT) and daily infusion of granulocyte colony stimulating factor (G-CSF) for malignant tumors in adults |
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