High dose chemotherapy followed by autologous bone marrow transplantation (ABMT) and daily infusion of granulocyte colony stimulating factor (G-CSF) for malignant tumors in adults

• Published in: Journal of the Japan Society of the Reticuloendothelial System Vol. 31; no. 5; pp. 479 - 486
• Main Authors: Kohno, Akio, Tamayose, Kenji, Shimoyama, Masanori, Hayashi, Masaki, Tobinai, Kensei, Takeyama, Kunihiko, Narabayashi, Masaru
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society for Lymphoreticular Tissue Research 1991
• ISSN: 0386-9725; 1883-6801
• DOI: 10.3960/jslrt1961.31.479

Fourteen adult patients with resistant malignant tumors (3 with malignant lymphoma, 3 with acute lymphocytic leukemia, 5 with recurrent breast cancer and 3 with germ cell tumor) received high dose chemotherapy followed by autologous bone marrow transplantation (ABMT) and daily infusion of granulocyte colony stimulating factor (G-CSF). All the 14 patients showed bone marrow engraftment. Median neutrophilic recovery over 500/cmm was 12 days after ABMT, and no life-threatening infection occurred during neutropenic period. As compared with literature controls of high dose chemotherapy followed by ABMT not using G-CSF in Western countries, our results showed earlier recovery of neutrophils. It is suggested that G-CSF may shorten neutropenic period after ABMT. Non-hematologic regimen-related toxicities were under control. No therapy-related death was observed. Disease oriented, multicenter phase II studies of high dose chemotherapy followed by ABMT and daily infusion of G-CSF are ongoing.