Quantitative systems modeling approaches towards model-informed drug development: Perspective through case studies

• Published in: Frontiers in Systems Biology (Online) Vol. 2
• Main Authors: Verma, Meghna, Gall, Louis, Biasetti, Jacopo, Di Veroli, Giovanni Y., Pichardo-Almarza, Cesar, Gibbs, Megan A., Kimko, Holly
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 12.01.2023
• Subjects: Computational modeling; model informed drug development; Quantitative systems pharmacology; quantitative systems toxicology; systems modeling

Quantitative systems pharmacology (QSP) modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions. In this paper, we highlight the notable contr...