Quantitative systems modeling approaches towards model-informed drug development: Perspective through case studies

Quantitative systems pharmacology (QSP) modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions. In this paper, we highlight the notable contr...

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Bibliographic Details
Published inFrontiers in Systems Biology (Online) Vol. 2
Main Authors Verma, Meghna, Gall, Louis, Biasetti, Jacopo, Di Veroli, Giovanni Y., Pichardo-Almarza, Cesar, Gibbs, Megan A., Kimko, Holly
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 12.01.2023
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Summary:Quantitative systems pharmacology (QSP) modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions. In this paper, we highlight the notable contributions and opportunities that QSP approaches are to offer during the drug development process by sharing three examples that have facilitated internal decisions. The barriers to successful applications and the factors that facilitate the success of the modeling approach is discussed.
ISSN:2674-0702
2674-0702
DOI:10.3389/fsysb.2022.1063308