Quantitative systems modeling approaches towards model-informed drug development: Perspective through case studies

Quantitative systems pharmacology (QSP) modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions. In this paper, we highlight the notable contr...

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Published inFrontiers in Systems Biology (Online) Vol. 2
Main Authors Verma, Meghna, Gall, Louis, Biasetti, Jacopo, Di Veroli, Giovanni Y., Pichardo-Almarza, Cesar, Gibbs, Megan A., Kimko, Holly
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 12.01.2023
Subjects
Computational modeling
model informed drug development
Quantitative systems pharmacology
quantitative systems toxicology
systems modeling
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Abstract Quantitative systems pharmacology (QSP) modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions. In this paper, we highlight the notable contributions and opportunities that QSP approaches are to offer during the drug development process by sharing three examples that have facilitated internal decisions. The barriers to successful applications and the factors that facilitate the success of the modeling approach is discussed.
AbstractList Quantitative systems pharmacology (QSP) modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions. In this paper, we highlight the notable contributions and opportunities that QSP approaches are to offer during the drug development process by sharing three examples that have facilitated internal decisions. The barriers to successful applications and the factors that facilitate the success of the modeling approach is discussed.
Author Gall, Louis
Verma, Meghna
Pichardo-Almarza, Cesar
Gibbs, Megan A.
Biasetti, Jacopo
Kimko, Holly
Di Veroli, Giovanni Y.
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SubjectTerms Computational modeling
model informed drug development
Quantitative systems pharmacology
quantitative systems toxicology
systems modeling
Title Quantitative systems modeling approaches towards model-informed drug development: Perspective through case studies
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