Synthesis and Characterization of Some Schiff Bases Derived from Carboxymethyl Chitosan and Evaluating The Biological Activity of Some of these Derivatives

This study included the synthesis of O-carboxymethyl chitosan which contains amine group attached directly to its glucose unit from the well-known natural polymer (chitosan), which in turn was reacted with some aromatic aldehydes containing o- and p- substituents to prepare a series of Schiff bases...

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Bibliographic Details
Published inKirkuk Journal of Science Vol. 15; no. 4; pp. 56 - 86
Main Authors Al-kadhimi, Ahmed, Muhsin, Moneer Khadhim, Al-Salami, Marwan Ahmed Jassim
Format Journal Article
LanguageEnglish
Published University of Kirkuk 02.01.2021
Subjects
carboxymethyl chitosan schiff bases
chitosan
o-carboxymethyl chitosan
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Summary:This study included the synthesis of O-carboxymethyl chitosan which contains amine group attached directly to its glucose unit from the well-known natural polymer (chitosan), which in turn was reacted with some aromatic aldehydes containing o- and p- substituents to prepare a series of Schiff bases compounds. The used aldehydes were; p-boromobenzaldehyde, o-hydroxybenzaldehyde, o-bromobenzaldehyde, p-chlorobenzaldehyde, and p-nitrobenzaldehyde. The synthesized compounds were characterized using spectroscopic techniques including FT-IR and 1H-NMR. The thermal stability of some of the prepared compounds was checked using differential thermaogravimetric analysis DTA. Finally, the biological activity of two Schiff bases was measured against two types of bacteria (Escherichia coli) and (Staphylococcus aureus) in terms of inhibition rate.
ISSN:2616-6801
3005-4788
2616-6801
3005-4796
DOI:10.32894/kujss.2021.167518