Fluoro-Benzylphosphonates as Reagents for the Preparation of 1-Fluoro-1-Aryl Alkenes and ?-Fluorostilbenes

The preparation of several fluoro-benzylphosphonates Ar-CHF-PO(OEt)2 and their Wadsworth-Emmons type olefination with aldehydes and ketones are described affording fluorostyrenes and fluorostilbenes. Some of these compounds are incorporated into target molecules tested as drug candidates.

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Bibliographic Details
Published inChimia Vol. 58; no. 3
Main Authors Thomas Allmendinger, Roger Fujimoto, Fabrizio Gasparini, Walter Schilling, Yoshi Satoh
Format Journal Article
LanguageGerman
Published Swiss Chemical Society 01.03.2004
Subjects
Fluoro-benzylphosphonates
Fluoroolefins
Horner-wadsworth-emmons olefination
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Summary:The preparation of several fluoro-benzylphosphonates Ar-CHF-PO(OEt)2 and their Wadsworth-Emmons type olefination with aldehydes and ketones are described affording fluorostyrenes and fluorostilbenes. Some of these compounds are incorporated into target molecules tested as drug candidates.
ISSN:0009-4293
2673-2424
DOI:10.2533/000942904777678217