Drug Delivery: Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)

Coronary heart disease is the main cause of death worldwide, the endocardium being the most vulnerable region for myocardial ischemia. In article number 1701276, by Mónica P. A. Ferreira, Heikki Ruskoaho, Anu J. Airaksinen, Hélder A. Santos, and co‐workers, the development of a multifunctional nanop...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 13; no. 33
Main Authors Ferreira, Mónica P. A., Ranjan, Sanjeev, Kinnunen, Sini, Correia, Alexandra, Talman, Virpi, Mäkilä, Ermei, Barrios‐Lopez, Brianda, Kemell, Marianna, Balasubramanian, Vimalkumar, Salonen, Jarno, Hirvonen, Jouni, Ruskoaho, Heikki, Airaksinen, Anu J., Santos, Hélder A.
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.09.2017
Subjects
Cardiovascular disease
drug delivery
Drug delivery systems
endocardium
Heart
Ischemia
ischemic heart
multifunctional nanoparticles
Nanoparticles
Nanotechnology
targeting
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Summary:Coronary heart disease is the main cause of death worldwide, the endocardium being the most vulnerable region for myocardial ischemia. In article number 1701276, by Mónica P. A. Ferreira, Heikki Ruskoaho, Anu J. Airaksinen, Hélder A. Santos, and co‐workers, the development of a multifunctional nanoparticle with cardioprotective potential is reported, which selectively targets the endocardial layer of the left ventricle upon intravenous injection and delivers a drug molecule for modulating the hypertrophic signaling.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201770177