The aging lipidome: exercise is medicine

The molecular mechanisms behind the potential ‘anti-aging’ effects of exercise remain to be elucidated. Janssens et al. studied the lipidome of different mouse tissues and human skeletal muscle. They identified an evolutionary conserved ‘lipid aging’ signature, characterized by bis(monoacylglycero)p...

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Bibliographic Details
Published inTrends in molecular medicine Vol. 30; no. 11; pp. 1001 - 1003
Main Authors Plaza-Florido, Abel, Pérez-Prieto, Inmaculada, Lucia, Alejandro
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 24.06.2024
Subjects
lipidomics
older adults
omics
physical activity
older adults
omics
lipidomics
physical activity
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Summary:The molecular mechanisms behind the potential ‘anti-aging’ effects of exercise remain to be elucidated. Janssens et al. studied the lipidome of different mouse tissues and human skeletal muscle. They identified an evolutionary conserved ‘lipid aging’ signature, characterized by bis(monoacylglycero)phosphate accumulation, which, at the muscle level, can be attenuated by exercise. The molecular mechanisms behind the potential ‘anti-aging’ effects of exercise remain to be elucidated. Janssens et al. studied the lipidome of different mouse tissues and human skeletal muscle. They identified an evolutionary conserved ‘lipid aging’ signature, characterized by bis(monoacylglycero)phosphate accumulation, which, at the muscle level, can be attenuated by exercise.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1471-4914
1471-499X
1471-499X
DOI:10.1016/j.molmed.2024.06.006