A study on platelet function, blood coagulability and fibrinolytic activity in ischemic heart disease, lone atrial fibrillation and diabetes mellitus

The purpose of this study is to evaluate the platelet function, blood coagulability and fibrinolytic activity in ischemic heart disease (IHD), lone atrial fibrillation (lone Af), diabetes mellitus (DM) and normal controls (Normal). Blood samples were obtained from the antecubital vein. Measurements...

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Published inBlood & Vessel Vol. 17; no. 4; pp. 335 - 339
Main Authors FURUI, Hirohiko, UKAI, Masahiko, IWASE, Mitsunori, INAGAKI, Haruo, SUZUKI, Toshikazu, KAMIHARA, Susumu, TANIGUCHI, Naoki, KOIDE, Masafumi, YOKOTA, Mitsuhiro, YAMAUCHI, Kazunobu, HAYASHI, Hiroshi, SOTOBATA, Iwao, SAITO, Hidehiko
Format Journal Article
LanguageEnglish
Published The Japanese Society on Thrombosis and Hemostasis 1986
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Summary:The purpose of this study is to evaluate the platelet function, blood coagulability and fibrinolytic activity in ischemic heart disease (IHD), lone atrial fibrillation (lone Af), diabetes mellitus (DM) and normal controls (Normal). Blood samples were obtained from the antecubital vein. Measurements were made for platelet counts in whole blood and platelet rich plasma (PRP), platelet sensitivity to ADP-aggregation and plasma concentrations of β-thromboglobulin (β-TG), fibrinogen (Fbg), antithrombin III (AT III), α2-plasmin inhibitor (α2-PI) and protein C. Patients with DM showed a higher β-TG level than Normal (DM: 122.3±68.3ng/ml; Normal: 32.4±10.8ng/ml, p<0.001) although there were no significant differences in platelet counts and sensitivity to ADP-aggregation. Patients with IHD showed higher levels of α2-PI (IHD: 5.47±0.83mg/dl; Normal: 4.45±0.68mg/dl, p<0.01) and Fbg (IHD: 402.3±76.7mg/dl; Normal: 310.5±41.9mg/dl, p<0.001) compared with Normal. Lower levels of AT III were observed in lone Af and IHD than in Normal (lone Af: 24.1±4.0mg/dl, IHD: 25.3±3.3mg/dl, Normal: 27.5±3.6mg/dl; IHD vs Normal: p<0.05, lone Af vs Normal: p<0.01). In conclusion, the hypercoagulable state observed in IHD, lone Af and DM may be related to a high incidence of thromboembolism in these diseases.
ISSN:0386-9717
1884-2372
DOI:10.2491/jjsth1970.17.335