A study on platelet function, blood coagulability and fibrinolytic activity in ischemic heart disease, lone atrial fibrillation and diabetes mellitus
The purpose of this study is to evaluate the platelet function, blood coagulability and fibrinolytic activity in ischemic heart disease (IHD), lone atrial fibrillation (lone Af), diabetes mellitus (DM) and normal controls (Normal). Blood samples were obtained from the antecubital vein. Measurements...
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Published in | Blood & Vessel Vol. 17; no. 4; pp. 335 - 339 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
The Japanese Society on Thrombosis and Hemostasis
1986
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Subjects | |
Online Access | Get full text |
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Summary: | The purpose of this study is to evaluate the platelet function, blood coagulability and fibrinolytic activity in ischemic heart disease (IHD), lone atrial fibrillation (lone Af), diabetes mellitus (DM) and normal controls (Normal). Blood samples were obtained from the antecubital vein. Measurements were made for platelet counts in whole blood and platelet rich plasma (PRP), platelet sensitivity to ADP-aggregation and plasma concentrations of β-thromboglobulin (β-TG), fibrinogen (Fbg), antithrombin III (AT III), α2-plasmin inhibitor (α2-PI) and protein C. Patients with DM showed a higher β-TG level than Normal (DM: 122.3±68.3ng/ml; Normal: 32.4±10.8ng/ml, p<0.001) although there were no significant differences in platelet counts and sensitivity to ADP-aggregation. Patients with IHD showed higher levels of α2-PI (IHD: 5.47±0.83mg/dl; Normal: 4.45±0.68mg/dl, p<0.01) and Fbg (IHD: 402.3±76.7mg/dl; Normal: 310.5±41.9mg/dl, p<0.001) compared with Normal. Lower levels of AT III were observed in lone Af and IHD than in Normal (lone Af: 24.1±4.0mg/dl, IHD: 25.3±3.3mg/dl, Normal: 27.5±3.6mg/dl; IHD vs Normal: p<0.05, lone Af vs Normal: p<0.01). In conclusion, the hypercoagulable state observed in IHD, lone Af and DM may be related to a high incidence of thromboembolism in these diseases. |
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ISSN: | 0386-9717 1884-2372 |
DOI: | 10.2491/jjsth1970.17.335 |