Frontispiece: What Are We Missing by Not Measuring the Net Charge of Proteins?

The net electrostatic charge of most folded proteins has never been measured in solution at pH values different from the isoelectric point. The authors discuss how measuring the net electrostatic charge Z of folded, solvated proteins can provide new information about fundamental electrostatic proper...

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Bibliographic Details
Published inChemistry : a European journal Vol. 25; no. 32
Main Authors Zahler, Collin T., Shaw, Bryan F.
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 07.06.2019
Subjects
capillary electrophoresis
Chemistry
Electron transfer
Electrostatic charge
Electrostatic properties
electrostatics
metalloproteins
protein aggregation
Proteins
Static electricity
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Summary:The net electrostatic charge of most folded proteins has never been measured in solution at pH values different from the isoelectric point. The authors discuss how measuring the net electrostatic charge Z of folded, solvated proteins can provide new information about fundamental electrostatic properties of metalloproteins or about processes in which they are involved, for example, electron transfer or metal coordination. For more details see the Concept by B. F. Shaw and C. T. Zahler on page 7581 ff.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201983261