Engineered Phage with Aggregation‐Induced Emission Photosensitizer in Cocktail Therapy against Sepsis (Adv. Mater. 6/2023)

Sepsis Therapy In article number 2208578, Ming‐Yu Wu, Luojia Chen, Lianrong Wang, Shi Chen, Meijia Gu, and co‐workers develop a novel strategy combining an AIE photosensitizer with a phage that not only selectively identifies bacterial species but also shows a powerful ability to kill pathogenic bac...

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Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 35; no. 6
Main Authors Wu, Ming‐Yu, Chen, Luojia, Chen, Qingrong, Hu, Rui, Xu, Xiaoyu, Wang, Yifei, Li, Jie, Feng, Shun, Dong, Changjiang, Zhang, Xiao‐Lian, Li, Zhiqiang, Wang, Lianrong, Chen, Shi, Gu, Meijia
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.02.2023
Subjects
aggregation‐induced emission
Materials science
phage cocktail therapy
Phages
Photodynamic therapy
photosensitizers
sepsis
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Summary:Sepsis Therapy In article number 2208578, Ming‐Yu Wu, Luojia Chen, Lianrong Wang, Shi Chen, Meijia Gu, and co‐workers develop a novel strategy combining an AIE photosensitizer with a phage that not only selectively identifies bacterial species but also shows a powerful ability to kill pathogenic bacteria in sepsis diagnosis and treatment. This synergetic therapy strategy combining phage cocktail therapy and photodynamic therapy offers a strong “1 + 1 > 2” bactericidal efficacy in vitro and in vivo.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202370041