Studies on the Site and Mechanism of Action of Phenformin: I. Evidence for Significant “Nonperipheral” Effects of Phenformin on Glucose Metabolism in Normal Subjects

Oral and intravenous glucose tolerance tests were performed in ten normal subjects. Phenformin pretreatment flattened the glucose and insulin response to oral glucose loading but did not significantly alter the response to intravenous glucose. It is suggested that these results can best be explained...

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Published inDiabetes (New York, N.Y.) Vol. 19; no. 1; pp. 45 - 49
Main Authors Hollobaugh, Samuel L, Rao, M Bhaskar, Kruger, Fred A
Format Journal Article
LanguageEnglish
Published United States 01.01.1970
Subjects
Adult
Female
Glucose - metabolism
Glucose Tolerance Test
Humans
Injections, Intravenous
Intestinal Absorption - drug effects
Intestine, Small - drug effects
Male
Phenformin - pharmacology
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Summary:Oral and intravenous glucose tolerance tests were performed in ten normal subjects. Phenformin pretreatment flattened the glucose and insulin response to oral glucose loading but did not significantly alter the response to intravenous glucose. It is suggested that these results can best be explained by an inhibitory effect of the drug on the rate of intestinal glucose absorption.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0012-1797
1939-327X
DOI:10.2337/diab.19.1.45