Insulin in aluminum phosphide poisoning: A systematic review of the current literature

• Published in: Medicine (Baltimore) Vol. 103; no. 42; p. e40066
• Main Authors: Shukla, Ravi, Lamichhane, Kiran, Pandey, Dhritee, Gupta, Chandan Kumar, Shukla, Sashank
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 18.10.2024
• Subjects: Aluminum Compounds - poisoning; Humans; Hypoglycemic Agents - poisoning; Hypoglycemic Agents - therapeutic use; Insulin - therapeutic use; Pesticides - poisoning; Phosphines - poisoning; Poisoning - drug therapy; Poisoning - therapy; Systematic Review and Meta-Analysis
• ISSN: 1536-5964; 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000040066

Aluminum phosphide (AlP) is a commonly used fumigant in agriculture and grain preservation because of its high potency and low cost. Due to the absence of a specific antidote and promising treatment modality, poisoning with this substance is deadly. Amid multiple studies in different parts of the world, each exploring options like lavage, inotropes, antioxidants, etc, we conducted a systematic review to find the possible role of exogenous insulin in treating symptomatic cases of AlP poisoning. Experimental studies released before February 15, 2024, that reported the use of exogenous insulin were systematically reviewed following the Preferred Reporting Items for Systematic Review and Meta-Analysis statement. The search was done on PubMed Central, Cochrane Library, and Google Scholar. After applying the inclusion and exclusion criteria, we finalized a few scientific papers for the review. Studying data from 4 scientific papers (3 quasi-experimental studies and 1 randomized controlled trial), we could postulate the significant improvement in survivability after the inclusion of exogenous insulin in the treatment of poisoned cases of AlP. Studies showed divergent results for the blood pressure, blood gases, and need for mechanical ventilation. Hypoglycemia, hyperglycemia, and hypokalemia were the reported adverse effects of this therapy. Our review found that the use of exogenous insulin in AlP poisoning reduced mortality rates, which was consistent across all studies. With available knowledge, its inclusion as a part of therapy might be beneficial in AlP poisoning, but to put it forward confidently, we still need high-quality randomized control trials. It is indeed a subject of interest for future research.