Photodynamic therapy and nuclear imaging activities of zinc phthalocyanine‐integrated TiO2 nanoparticles in breast and cervical tumors

• Published in: Chemical biology & drug design Vol. 91; no. 3; pp. 789 - 796
• Main Authors: Yurt, Fatma, Ocakoglu, Kasim, Ince, Mine, Colak, Suleyman Gokhan, Er, Ozge, Soylu, Hale Melis, Gunduz, Cumhur, Biray Avci, Cıgır, Caliskan Kurt, Cansu
• Format: Journal Article
• Language: English
• Published: 01.03.2018
• Subjects: cell culture; nuclear imaging; photodynamic therapy; titanium nanoparticle; zinc phthalocyanine
• ISSN: 1747-0277; 1747-0285
• DOI: 10.1111/cbdd.13144

In recent years, phthalocyanines (Pcs) have been widely used as photosensitizer in photodynamic therapy applications. Because of their strong absorptions in the near‐infrared region (640–700 nm). The integration of phthalocyanine derivatives to a nanoparticle is expected to be efficient way to improve the activity of the photosensitizer on the targeted tissue. It is known that the integrated molecules not only show better accumulation on tumor tissue but also reduce toxicity in healthy tissues. In this study, the ZnPc molecule was synthesized and integrated to the TiO2 nanoparticle, to investigate the potential of PDT and its cytotoxicity. Additionally, ZnPc and ZnPc‐TiO2 molecules were labeled with 131I and it was aimed to put forth the nuclear imaging/therapy potentials of 131I labeled ZnPc/ZnPc‐TiO2 by determining in vitro uptakes in mouse mammary carcinoma (EMT6), human cervical adenocarcinoma (HeLa). In result of our study, it was observed that the radiolabeling yields of the synthesized ZnPc and ZnPc‐TiO2 with 131I were quite high. In vitro uptake studies shown that 131I‐ZnPc‐TiO2 could be a potential agent for nuclear imaging/treatment of breast and cervical cancers. According to PDT results, ZnPc‐TiO2 might have as to be a potential PDT agent in the treatment of cervical tumor. ZnPc and ZnPc‐TiO2 might be used as theranostic agents. New phthalocyanine and TiO2 integrated phthalocyanine were synthesized and their nuclear imaging and PDT potentials were evaluated in tumor cell lines.