CAP37, a Novel Inflammatory Mediator

Cationic antimicrobial protein of 37 kd (CAP37), originally isolated from human neutrophils, is an important multifunctional inflammatory mediator. Here we describe its localization within the vascular endothelium associated with atherosclerotic plaques. Evidence from in vitro immunocytochemical, No...

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Published inThe American journal of pathology Vol. 160; no. 3; pp. 841 - 848
Main Authors Lee, Taunia D., Gonzalez, Melva L., Kumar, Padmasini, Chary-Reddy, Saritha, Grammas, Paula, Pereira, H. Anne
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.03.2002
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Summary:Cationic antimicrobial protein of 37 kd (CAP37), originally isolated from human neutrophils, is an important multifunctional inflammatory mediator. Here we describe its localization within the vascular endothelium associated with atherosclerotic plaques. Evidence from in vitro immunocytochemical, Northern blot, and reverse transcriptase-polymerase chain reaction analysis indicates that CAP37 is induced in endothelial cells in response to inflammatory mediators. Endothelial-derived CAP37 shows sequence identity with an extensive region of neutrophil-derived CAP37. This is the first demonstration of endogenous endothelial CAP37, confirmed by sequence analysis. We suggest that, because of its induction and location in the endothelium and its known monocyte- and endothelial-activating capabilities, CAP37 has potential to modulate monocyte/endothelial dynamics at the vessel wall in inflammation.
ISSN:0002-9440
1525-2191
DOI:10.1016/S0002-9440(10)64907-3