Alteration of complement value in healthy male subjects Long term observation in 9 healthy male subjects

• Published in: Japanese Journal of Clinical Immunology Vol. 11; no. 1; pp. 40 - 44
• Main Authors: Ito, Tetsuro, Ohi, Hiroyuki, Seki, Masato, Fujita, Takayuki, Kojima, Hiroyuki, Watanabe, Shizuhiko, Okano, Kikuo, Ikezawa, Tetsuro, Ohmori, Fumihiko, Hatano, Michinobu
• Format: Journal Article
• Language: English
• Published: The Japan Society for Clinical Immunology 1988
• Subjects: CH 50; physiological variations
• ISSN: 0911-4300; 1349-7413
• DOI: 10.2177/jsci.11.40

Total hemolytic complement (CH 50) and the serum levels of C3 and C4 were measured in 9 healthy male subjects for three months every week, in order to demonstrate the intra-individual variation in healthy subjects. The mean values of intra-individual physiological variations in 9 subjects were as follows; CH 50: Standard Deviation (SD) 2.0unit/ml and Coefficient of Variation (CV) 5.0%, C3: SD 14% and CV 10%, and C4: SD 15% and CV 12%. There was no correlation between CH 50 and the serum levels of C3 and C4. Hypocomplementemia was not seen. Elevated levels of CH 50 were observed in 5 subjects when they showed signs of common cold. It may be important in assessing alterations of complement value in various disease states to consider about such intra-individual variations of complement in healthy subjects.