Synthesis of unlabelled, 3H- and 125I-labelled β-CIT and its ϖ-fluoroalkyl analogues β-CIT-FE and β-CIT-FP, including synthesis of precursors
The full synthesis of the cocaine congener 2β‐carbomethoxy‐3β‐(4‐iodophenyl)tropane (β‐CIT) and its N‐fluoroalkyl analogues, fluoroethyl‐ and fluoropropyl‐nor‐β‐CIT (β‐CIT‐FE and β‐CIT‐FP) starting from cocaine is described. The synthetic routes include the preparation of precursors for labelling wi...
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Published in | Journal of labelled compounds & radiopharmaceuticals Vol. 38; no. 7; pp. 675 - 685 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester
John Wiley & Sons, Ltd
01.07.1996
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Subjects | |
Online Access | Get full text |
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Summary: | The full synthesis of the cocaine congener 2β‐carbomethoxy‐3β‐(4‐iodophenyl)tropane (β‐CIT) and its N‐fluoroalkyl analogues, fluoroethyl‐ and fluoropropyl‐nor‐β‐CIT (β‐CIT‐FE and β‐CIT‐FP) starting from cocaine is described. The synthetic routes include the preparation of precursors for labelling with radionuclides such as 11C, 18F, 76Br, 123I, 125I and 3H. Here we also report the labelling with 125I or 3H for use in autoradiographic examination of human brain sections. |
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Bibliography: | Swedish Medical Research Council - No. 03560, 09114 Kasolinska Institutet istex:560A460195F89E5418A9341E17BE115340E1A1D1 ark:/67375/WNG-D0CTRV1B-3 Swedish Natural Research Council - No. K-KU 9973-307 ArticleID:JLCR880 |
ISSN: | 0362-4803 1099-1344 |
DOI: | 10.1002/(SICI)1099-1344(199607)38:7<675::AID-JLCR880>3.0.CO;2-L |