Evaluation of 18F-AlF-labeled IF7 dimer as a promising molecular probe for tumor targeting PET imaging in mice

Molecular imaging technologies, such as PET imaging, have evolved into powerful tools for tumor diagnosis. Radiolabeled dimeric molecular probes have emerged as a promising strategy in PET imaging due to their outstanding characteristics. IF7, a peptide targeting Anxa1 overexpressed in endothelial c...

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Bibliographic Details
Published inJournal of radioanalytical and nuclear chemistry Vol. 333; no. 4; pp. 2059 - 2068
Main Authors Du, Zhigang, Xue, Xinyu, Liao, Wenfang, Gao, Qinyue, Chen, Fei, Zhu, Bao
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.04.2024
Springer Nature B.V
Subjects
Biological properties
Blood vessels
Chemistry
Chemistry and Materials Science
Diagnosis
Diagnostic Radiology
Dimers
Endothelial cells
Hadrons
Heavy Ions
Imaging
Inorganic Chemistry
Nuclear Chemistry
Nuclear Physics
Peptides
Performance evaluation
Physical Chemistry
Positron emission
Tumors
Al
PET imaging
F
Dimeric molecular probe
Annexin-A1
GGGRDN-IF7
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Summary:Molecular imaging technologies, such as PET imaging, have evolved into powerful tools for tumor diagnosis. Radiolabeled dimeric molecular probes have emerged as a promising strategy in PET imaging due to their outstanding characteristics. IF7, a peptide targeting Anxa1 overexpressed in endothelial cells of various tumor blood vessels, serves as an excellent tumor-targeting agent. This research aims to prepare IF7 dimer and evaluate its imaging performance and biological characteristics. The biological properties of the tracer were evaluated through in vitro experiments using U87 cells. MicroPET imaging and biodistribution were also studied in tumor-bearing mice. MicroPET studies showed a high tumor uptake at 30 and 60 min post-injection with 4.09 ± 0.83%ID/g and 2.66 ± 0.55%ID/g, respectively. Co-injection of excess nonradiolabelled peptide significantly reduced tumor uptake at 30 min (0.33 ± 0.15%ID/g), confirming the tumor-targeting specificity of IF7 dimer. The IF7 dimer tracer demonstrated excellent imaging performance as a tumor-targeting molecular probe, indicating potential clinical applicability and offering new possibilities for future early tumor diagnosis. Graphical abstract
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-024-09391-z