Ruthenium-catalyzed regioselective N-directed C–H olefination of 2-phenylphthalazinone

The 2-phenylphthalazinone derivatives are the main skeleton of various pharmaceuticals. In this work, an efficient method for the regioselective Ru(II)-organometallic complex-catalyzed alkenylation of 2-phenylphthalazinone through N -directing group via C–H activation process is presented. The resul...

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Bibliographic Details
Published inChemical papers Vol. 76; no. 9; pp. 5523 - 5532
Main Authors Dabiri, Minoo, Alavioon, Seyed Iman
Format Journal Article
LanguageEnglish
Published Warsaw Versita 01.09.2022
Springer Nature B.V
Subjects
Biochemistry
Biotechnology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Industrial Chemistry/Chemical Engineering
Materials Science
Medicinal Chemistry
Original Paper
Regioselectivity
Ruthenium
Substrates
Directing group
C–H activation
Organometallic complex
2-Phenylphthalazinone
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Summary:The 2-phenylphthalazinone derivatives are the main skeleton of various pharmaceuticals. In this work, an efficient method for the regioselective Ru(II)-organometallic complex-catalyzed alkenylation of 2-phenylphthalazinone through N -directing group via C–H activation process is presented. The results have proved to be satisfactory for a wide range of yields bearing an electron-donating and electron-withdrawing groups on substrates. Graphical abstract
ISSN:0366-6352
1336-9075
2585-7290
DOI:10.1007/s11696-022-02221-0