The post-thrombotic syndrome - a condition to prevent

• Published in: Dermatology online journal Vol. 14; no. 3; p. 13
• Main Authors: Pirard, Delphine, Bellens, Bernard, Vereecken, Pierre
• Format: Journal Article
• Language: English
• Published: United States 15.03.2008
• Subjects: Anticoagulants - therapeutic use; Erysipelas - etiology; Erysipelas - pathology; Humans; Leg Dermatoses - etiology; Leg Dermatoses - pathology; Lymphangiosarcoma - etiology; Lymphedema - etiology; Lymphedema - pathology; Postthrombotic Syndrome - diagnosis; Postthrombotic Syndrome - etiology; Postthrombotic Syndrome - prevention & control; Skin - pathology; Skin Care; Skin Neoplasms - etiology; Stockings, Compression; Venous Thrombosis - complications; Venous Thrombosis - therapy
• ISSN: 1087-2108; 1087-2108
• DOI: 10.5070/D36XC40751

The incidence of the post-thrombotic syndrome (PTS) is increasing along with the incidence of deep vein thrombosis (DVT). The overall frequency of PTS ranges from 20 percent to 50 percent of DVT patients; severe PTS, which includes leg ulcers, occurs in a quarter of cases. Because of its severity and chronicity, PTS is associated with great morbidity and cost. Its diagnosis is primarily based on the presence of typical symptoms and signs, but objective evidence of venous valvular reflux can help to confirm the diagnosis. Because therapeutic options for PTS are extremely limited and results are often disappointing, prevention, recognition of clinical signs or complications, and early treatment remain the keys to reducing its morbidity. The prevention of DVT recurrence by anticoagulation and use of graduated compression stockings is likely to reduce the risk of PTS. There is no proven role for thrombolysis in preventing PTS.