Hashimoto's thyroiditis with granulomas: A unifying immunological etiology?

Two cases of granulomatous inflammation of the thyroid gland associated with Hashimoto's thyroiditis are presented. In neither case is there an obvious cause of granuloma formation, the only accompanying abnormality being rheumatoid arthritis in one of the patients. Autoimmune thyroid disease h...

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Bibliographic Details
Published inEndocrine pathology Vol. 3; no. 1; p. 52
Main Authors Driman, David K, Asa, Sylvia L, Murray, David, Goluboff, Lanny G, Shaw, Ralph W
Format Journal Article
LanguageEnglish
Published United States 01.03.1992
Subjects
Thyroiditis
Granulomatous Inflammation
Rheumatoid Arthritis
Sarcoidosis
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Summary:Two cases of granulomatous inflammation of the thyroid gland associated with Hashimoto's thyroiditis are presented. In neither case is there an obvious cause of granuloma formation, the only accompanying abnormality being rheumatoid arthritis in one of the patients. Autoimmune thyroid disease has been reported in association with sarcoidosis as well as rheumatoid arthritis, diseases in which cellular immunity is activated. Immune mechanisms alone are capable of initiating and amplifying granulomatous inflammation. In this report, we suggest that the granulomas in both cases may have their origin in immunological malfunction, the same immunological malfunction responsible for Hashimoto's thyroiditis.
ISSN:1559-0097
DOI:10.1007/BF02921344