Effects of pentobarbital and ketamine-xylazine anaesthesia on somatosensory, brainstem auditory and peripheral sensorymotor responses in the rat

Somatosensory, brainstem auditory evoked and peripheral sensory-motor responses were recorded in rats anaesthetized with either pentobarbital or a ketamine-xylazine combination. This was carried out in order to assess which of these agents degraded responses to a lesser extent and thus would be more...

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Bibliographic Details
Published inLaboratory animals (London) Vol. 25; no. 4; pp. 360 - 366
Main Authors Goss-Sampson, M. A., Kriss, A.
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.10.1991
Subjects
BRAINSTEM AUDITORY EVOKED POTENTIALS
H REFLEXES
RAT
SOMATOSENSORY EVOKED POTENTIALS
ANAESTHESIA
KETAMINE
XYLAZINE PENTOBARBITAL
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Summary:Somatosensory, brainstem auditory evoked and peripheral sensory-motor responses were recorded in rats anaesthetized with either pentobarbital or a ketamine-xylazine combination. This was carried out in order to assess which of these agents degraded responses to a lesser extent and thus would be more suitable for monitoring experimental effects. Neither of the anaesthetic agents affected peripheral sensory or motor conduction, nor were there any interpeak latency changes of the early components of the brainstem auditory response. However, pentobarbital anaesthesia resulted in an increase in latency of the initial positive component of the somatosensory cortical evoked potential and attenuation of the following negative component. During the recovery stages of ketamine-xylazine anaesthesia the longer latency evoked potential components were observed to emerge.
ISSN:0023-6772
1758-1117
DOI:10.1258/002367791780810074