Side effect profile and adherence to in the treatment of Multiple Sclerosis with interferon beta-la

This study examines the course of patient-reported side effect during the first 4 months of treatment for multiple sclerosis (MS) with interferon beta-Ia (IFNβ-Ia), and the relationship of those side effects to discontinuation of medication. Flu-like symptoms, muscle aches and chills decreased over...

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Bibliographic Details
Published inMultiple sclerosis Vol. 4; no. 6; pp. 487 - 489
Main Authors Mohr, David C, Likosky, William, Boudewyn, Arne C, Marietta, Peter, Dwyer, Pat, Van Der Wende, Judy, Goodkin, Donald E
Format Journal Article
LanguageEnglish
Published Thousand Oaks, CA SAGE Publications 01.12.1998
Subjects
side effects
interferon
multiple sclerosis
compliance
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Summary:This study examines the course of patient-reported side effect during the first 4 months of treatment for multiple sclerosis (MS) with interferon beta-Ia (IFNβ-Ia), and the relationship of those side effects to discontinuation of medication. Flu-like symptoms, muscle aches and chills decreased over the first 2 months of treatment but did not change over the second 2 months. Loss of feeling or numbness, tingling and depression increased over 4 months, however these side effects were generally mild. Loss of feeling or numbness and tingling at 2 month follow-up were significantly related to discontinuation of IFNβ-Ia by 4 month follow-up.
ISSN:1352-4585
1477-0970
DOI:10.1177/135245859800400605