Green route for the synthesis of 3-substituted indoles using [bmim]HSO4 as non-halogenated ionic liquid

In this paper, an effective procedure is reported for the synthesis of 3-substituted indoles via the one-pot three-component reaction of an aldehyde, malononitrile or ethyl cyanoacetate and indole in the presence of [bmim]HSO 4 in ethanol under reflux condition. The advantages of this protocol are t...

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Bibliographic Details
Published inMonatshefte für Chemie Vol. 152; no. 6; pp. 659 - 664
Main Authors Shekarchi, Maral, Behbahani, Farahnaz K., Shekarchi, Maryam
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 01.06.2021
Springer Nature
Springer Nature B.V
Subjects
Aldehydes
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Ethanol
Indoles
Inorganic Chemistry
Ionic liquids
Ions
Malononitrile
Organic Chemistry
Original Paper
Physical Chemistry
Physical Sciences
Science & Technology
Substitutes
Theoretical and Computational Chemistry
3-Substituted indoles
One-pot
bmim
HSO
Ionic liquid
HSO4
CATALYZED MULTICOMPONENT SYNTHESIS
NANOCOMPOSITE
EFFICIENT
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Summary:In this paper, an effective procedure is reported for the synthesis of 3-substituted indoles via the one-pot three-component reaction of an aldehyde, malononitrile or ethyl cyanoacetate and indole in the presence of [bmim]HSO 4 in ethanol under reflux condition. The advantages of this protocol are the synthesis of some novel 3-substituted indoles containing furyl, 4-hydroxyphenyl, and styryl nuclei that are very important in pharmaceutical and drug discovery research in comparison to previously reported results, and the use of non-halogenated ionic liquid. Graphic abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-021-02782-y