Precisely tuned antibodies nab HIV

Newly discovered neutralizing antibodies that target sites on the envelope proteins of HIV-1 provide a window on how some of the most powerful of these antibodies acquire their potency and breadth of activity. See Letter p.466 Neutralizing antibodies for HIV/AIDS therapy Antibodies that can neutrali...

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Bibliographic Details
Published inNature (London) Vol. 477; no. 7365; pp. 416 - 417
Main Authors Clapham, Paul R., Lu, Shan
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 22.09.2011
Nature Publishing Group
Subjects
631/154
631/250/590
631/326/596
Binding sites
Humanities and Social Sciences
Immunization
Medical research
multidisciplinary
Mutation
news-and-views
Science
Science (multidisciplinary)
Vaccines
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Summary:Newly discovered neutralizing antibodies that target sites on the envelope proteins of HIV-1 provide a window on how some of the most powerful of these antibodies acquire their potency and breadth of activity. See Letter p.466 Neutralizing antibodies for HIV/AIDS therapy Antibodies that can neutralize many different strains of a virus — known as broadly neutralizing antibodies — are the focus of the search for a universal flu vaccine. Dennis Burton and colleagues report the isolation of a new panel of monoclonal antibodies with broad neutralizing activity against HIV that could be promising as immunotherapeutics. The antibodies recognize novel glycosylated epitopes on the viral spike, and some are ten times more potent than previously reported antibodies.
ISSN:0028-0836
1476-4687
DOI:10.1038/477416a