Domino Oxidative Cyclization of 2-Amino­acetophenones for the One-Pot Synthesis of Tryptanthrin Derivatives

A new CuI/DMSO‐mediated oxidative domino process has been developed for the synthesis of tryptanthrin derivatives. This is the first example of the synthesis of tryptanthrin derivatives directly from 2‐aminoaryl methyl ketones and isatoic anhydrides through copper‐promoted oxidative functionalizatio...

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Bibliographic Details
Published inEuropean journal of organic chemistry Vol. 2015; no. 36; pp. 8018 - 8022
Main Authors Reddy, B. V. Subba, Reddy, D. Maheswara, Reddy, G. Niranjan, Reddy, M. Ramana, Reddy, V. Krishna
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.12.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
1-b]­quinazolines
2-Aminoacetophenone
Indolo
Indolo[2,1‐b]­quinazolines
Isatoic anhydride
Nitrogen ­heterocycles
Synthetic methods
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Summary:A new CuI/DMSO‐mediated oxidative domino process has been developed for the synthesis of tryptanthrin derivatives. This is the first example of the synthesis of tryptanthrin derivatives directly from 2‐aminoaryl methyl ketones and isatoic anhydrides through copper‐promoted oxidative functionalization. A new DMSO/CuI‐catalysed oxidative domino process has been developed for the one‐pot synthesis of tryptanthrin derivatives.
Bibliography:ark:/67375/WNG-XR4LKRRB-6
istex:A25E4F67F7504E3A7E79B1BE3B84A1A13783BB53
ArticleID:EJOC201501079
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201501079