Retinal toxicity following intra‐vitreal injections of melphalan

Summary We report a retinal toxicity grading system as observed in a cohort of 110 retinoblastoma eyes treated by intra‐vitreal injections of melphalan to control vitreous seeding. By definition grade 1 and 2 correspond to a salt and pepper retinopathy anterior to the equator of 2 quadrants and 2 qu...

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Bibliographic Details
Published inActa ophthalmologica (Oxford, England) Vol. 94; no. S256
Main Authors Munier, F., Gaillard, M.C., Stathopoulos, C., Beck‐Popovic, M.
Format Journal Article
LanguageEnglish
Published Malden Wiley Subscription Services, Inc 01.10.2016
Subjects
Atrophy
Cancer
Melphalan
Ophthalmology
Optic nerve
Retina
Retinoblastoma
Retinopathy
Salts
Toxicity
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Summary:Summary We report a retinal toxicity grading system as observed in a cohort of 110 retinoblastoma eyes treated by intra‐vitreal injections of melphalan to control vitreous seeding. By definition grade 1 and 2 correspond to a salt and pepper retinopathy anterior to the equator of 2 quadrants and 2 quadrants respectively; grade 3 any extension behind the equator, grade 4 extension involving the macula and grade 5 diffuse retinopathy with optic nerve atrophy. In our series grade 4 and 5 toxicity could be avoided in 100% of the cases. We conclude that our injection technique is safe enough to prevent severe sight‐threatening toxicity.
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2016.0218