INSULIN SENSITIVITY TEST IN VARIOUS THYROID DISEASES

• Published in: Kita Kantō igaku (The Kitakanto Medical Journal) Vol. 10; no. 3; pp. 407 - 420
• Main Author: SHIOZAWA, Shinji
• Format: Journal Article
• Language: English
• Published: The Kitakanto Medical Society 1960
• ISSN: 0023-1908; 1883-6135
• DOI: 10.2974/kmj1951.10.3_407

Insulin sensitivity test was performed in various thyroid diseases, with the following results : 1) Out of 15 cases with Basedow's diseases, 11, who did not receive any treatment before, all showed the normal insulin value, which fell below the normal with improvement of the disease (8 cases). Those with low values in the beginning showed change in lower range. 3) Out of 23 cases with hyperthyroidism (in a narrow sense), 17 did not receive treatment in the past. Out of these 17, 8 showed the normal insulin value, and 9, lower values. For the former, excepting 3, the value decreased below the normal in the course of the treatment, and for the latter, it changed within lower range. 2) All the 5 cases with myxedema showed low insulin values, which tended to return to the normal in the course of treatment. 4) Out of 50 cases with simple goiter, 20% showed the normal insulin value, and 80%, lower values. Of the latter, 42% showed the normal recovery index, and 58% were delayed in recovery. Out of 39 cases with diffuse goiter, 5 (13%) showed the normal insulin value, and 34 (87%) lower values, while out of 11 cases with nodular goiter, 5 (45%) showed the normal, and 6 (55%), lower values. In this way, the percentage of the lower values was greater in the diffuse type (with significant difference at 0.02% level). In the course of treatment, insulin value returned to the normal in 50%, and approached to the normal in 50%. Those with the normal value before the treatment showed change within the normal range. 5) Further, insulin value was determined in other endocrinological diseases, diabetes insipidus, neurotic anorexia, Addison's disease, subacute thyroiditis, and thyroid cancer, and low insulin value was recognized.