Application of brain slice cultures for investigating neuronal sprouting

Axonal sprouting is a form of morphological plastic change of the neurons. It is proposed to underlie long-term changes in brain function and take place even in mature brain. Electriphysiological analysis revealed that chronic stress and antidepressants induce axonal degeneration and sprouting of lo...

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Bibliographic Details
Published inSeibutsu Butsuri Vol. 36; no. 4; pp. 176 - 180
Main Author SAKAGUCHI, Takuya
Format Journal Article
LanguageJapanese
English
Published The Biophysical Society of Japan General Incorporated Association 1996
Subjects
brain
hippocampus
locus coeruleus
neuron
slice culture
sprouting
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Summary:Axonal sprouting is a form of morphological plastic change of the neurons. It is proposed to underlie long-term changes in brain function and take place even in mature brain. Electriphysiological analysis revealed that chronic stress and antidepressants induce axonal degeneration and sprouting of locus coeruleus noradrenergic neurons in adult rat brain, respectively. Sprouing of hippocampal neurons was represented in the slice cultures of the hippocampus from 1-week old rat. This phenomenon was found to be specific for CA3 pyramidal neurons. Possible molecular mechanisms for neuron-specific morphological plasticity are discussed, referring to results from other laboratories.
ISSN:0582-4052
1347-4219
DOI:10.2142/biophys.36.176