Sequential changes of plasma soluble P-and E-selectins in acute to chronic phases of ischemic stroke

• Published in: Japanese Journal of Stroke Vol. 23; no. 3; pp. 234 - 239
• Main Authors: Kozuka, Kazuko, Kohriyama, Tatsuo, Nomura, Eiichi, Kajikawa, Hiroshi, Nakamura, Shigenobu
• Format: Journal Article
• Language: Japanese
• Published: The Japan Stroke Society 2001
• Subjects: endothelial cell; ischemic stroke; platelet; soluble E-selectin; soluble P-selectin
• ISSN: 0912-0726; 1883-1923
• DOI: 10.3995/jstroke.23.234

We sequentially measured the plasma soluble P-selectin (sP-selectin) and soluble E-selectin (sE-selectin) levels in patients with cerebral ischemia at three phases : within 48 hours, after one month and after 6 month from ictus. The plasma concentrations of sP-selectin were constantly increased from the acute phase to 6 months after ischemia, while the plasma concentrations of sE-selectin were elevated only at the acute phase, as compared with control subjects. The levels of sP- and sE-selectin appear to reach their peaks at 1 month after ictus in atherothrombotic infarction and at the acute phase in lacunar infarction. These findings could result from differences in the degree of platelet activation and/or extent of endothelial cell damage. The levels of sP-selectin were decreased in patients with atherothrombotic infarction treated with anti-platelet agents from 1 month to 6 months, as compared with patients treated without anti-platelet agents, reflecting the effect of anti-platelet agents. It should be emphasized that the levels of sP- and sE-selectin after cerebral ischemia fluctuate with pathophysiological changes such as platelet activation or endothelial cell damage, so that the sP-and sE-selectin levels could be useful for evaluating the effect of anti-platelet agents.