Sequential changes of plasma soluble P-and E-selectins in acute to chronic phases of ischemic stroke
We sequentially measured the plasma soluble P-selectin (sP-selectin) and soluble E-selectin (sE-selectin) levels in patients with cerebral ischemia at three phases : within 48 hours, after one month and after 6 month from ictus. The plasma concentrations of sP-selectin were constantly increased from...
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Published in | Japanese Journal of Stroke Vol. 23; no. 3; pp. 234 - 239 |
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Main Authors | , , , , |
Format | Journal Article |
Language | Japanese |
Published |
The Japan Stroke Society
2001
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Subjects | |
Online Access | Get full text |
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Summary: | We sequentially measured the plasma soluble P-selectin (sP-selectin) and soluble E-selectin (sE-selectin) levels in patients with cerebral ischemia at three phases : within 48 hours, after one month and after 6 month from ictus. The plasma concentrations of sP-selectin were constantly increased from the acute phase to 6 months after ischemia, while the plasma concentrations of sE-selectin were elevated only at the acute phase, as compared with control subjects. The levels of sP- and sE-selectin appear to reach their peaks at 1 month after ictus in atherothrombotic infarction and at the acute phase in lacunar infarction. These findings could result from differences in the degree of platelet activation and/or extent of endothelial cell damage. The levels of sP-selectin were decreased in patients with atherothrombotic infarction treated with anti-platelet agents from 1 month to 6 months, as compared with patients treated without anti-platelet agents, reflecting the effect of anti-platelet agents. It should be emphasized that the levels of sP- and sE-selectin after cerebral ischemia fluctuate with pathophysiological changes such as platelet activation or endothelial cell damage, so that the sP-and sE-selectin levels could be useful for evaluating the effect of anti-platelet agents. |
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ISSN: | 0912-0726 1883-1923 |
DOI: | 10.3995/jstroke.23.234 |