Changes in the blood tissue factor and its tissue factor pathway inhibitor in the acute phase of cerebral infarction

• Published in: Japanese Journal of Stroke Vol. 19; no. 3; pp. 203 - 211
• Main Authors: Yonenami, Koji, Narita, Nobuyoshi, Ichino, Takeshi, Sugihara, Hiroshi, Kamogawa, Asahi
• Format: Journal Article
• Language: Japanese
• Published: The Japan Stroke Society 1997
• Subjects: cerebral thrombosis; thrombinantithrombin III complex; thrombomodulin; tissue factor; tissue factor pathway inhibitor
• ISSN: 0912-0726; 1883-1923
• DOI: 10.3995/jstroke.19.203

In order to investigate the extrinsic coagulation in the acute phase of cerebral infarction, the changes in the tissue factor (TF) and its tissue factor pathway inhibitor (TFPI) in blood drawn from a lacunar brain infarction group, an atherothrombotic brain infarction group and a cardioembolic brain infarction group were compared with those of an age-matched control group consisting of normal subjects. Samples were examined on days 1 and 7 of the acute phase of the disease using the ELISA method. In addition, the clinical relevance of the data was evaluatd by determining the changes in thrombomodulin (TM) an indicator of endothelial cell injury, and thrombin-antithrombin III complex (TAT) which reflects hypercoagulability. TF in the lacunar brain infarction group and the atherothrombotic brain infarction group exhibited significantly lower values than those in the control group on both the 1st and 7th days of the disease. TFPI, on the other hand, showed no corresponding differences. However, the TFPI in the cardioembolic brain infarction group did reveal a high value compared to that in the control group. The blood.TM in each group was within the normal range. Nevertheless, a correlation between TM and TF was evident in the atherothrombotic brain infarction group. It appeared that the changes in TF might be partially attributable to endothelial cell injury. There was no correlation between TAT and TF or TFPI. However, a correlation did exist between prothrombin time and TF in the lacunar brain infarction group. These findings could indicate that early extrinsic coagulation before the production of thrombin influenced TF in the lacunar brain infarction group. Determinations of TF and TFPI are considered important for differentiating between various disease types in the acute phase of brain infarction and for elucidating the conditions that affect coagulation.