Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I 131 during Adolescence and Young Adulthood

• Published in: International journal of endocrinology Vol. 2016; pp. 1 - 7
• Main Authors: Metallo, Melanie, Groza, Lelia, Brunaud, Laurent, Klein, Marc, Weryha, Georges, Feigerlova, Eva
• Format: Journal Article
• Language: English
• Published: Hindawi Publishing Corporation 2016
• Subjects: Cancer; Endocrinology and metabolism; Human health and pathology; Life Sciences; Santé publique et épidémiologie; Therapy; Carcinoma; Radioiodine Ablation; Fatigue; Children; Care; Health Survey; SF-36; Information Needs
• ISSN: 1687-8337; 1687-8345
• DOI: 10.1155/2016/7586482

Introduction . Differentiated thyroid cancer (DTC) is rare and confers good prognosis. Long-term health related quality of life (HRQoL) and pregnancy outcomes are not well known in subjects treated during adolescence and young adulthood. Methods . Cross-sectional analysis of HRQoL and global self-esteem, using SF-36 and ISP-25 surveys, and of pregnancy outcomes in female survivors of DTC treated by total thyroidectomy and I 131 before age of 25 years. Results . Forty-five of 61 patients (74%) responded to the survey. Cumulative I 131 activity was ≤3.85 GBq in 18 subjects and >3.85 GBq in 27 subjects. Mean time from diagnosis was 7.6 ± 5.2 years for the group ≤ 3.85 GBq versus 16.9 ± 11.6 years for the group > 3.85 GBq ( P < 0.05 ). No significant alteration in long-term HRQoL and global self-esteem was observed. Thirty pregnancies after I 131 were noted in patients from the group > 3.85 GBq and 10 in patients from the group ≤ 3.85 GBq. Frequency of miscarriages was of 17% (group > 3.85 GBq) and 10% (group ≤ 3.85 GBq) with 9 and 24 live births, respectively. No congenital malformations or first year mortality was noted. Conclusion . Long-term HRQoL, global self-esteem, and pregnancy outcomes are not affected in young female survivors of DTC.