Report of a case: Primary biliary cirrhosis (PBC) associated with polymyositis (PM)

• Published in: Kanzo Vol. 27; no. 6; pp. 822 - 828
• Main Authors: SEKIYA, Chihiro, SUZUKI, Takahisa, SATOH, Hitoshi, NAMIKI, Masayoshi, TAKAHASHI, Atsushi, YAZAKI, Yasuyuki
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Hepatology 1986
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.27.822

A 58-year-old male suffered from PBC and PM is reported. He was admitted because of liver dysfunction chanced to be found by screening test asymptomatically. AMA and ANA (both homogeneous and speckled types) were positive. ALP and IgM levels were increased. Laparoscopic and histologic findings proved to be PBC (stage I). Two years after the diagnosis, he was re-admitted on account of muscle weakness and of increased CPK level (1321mU). Muscle biopsy findings were compatible with PM. Oral administration of prednisolone (45 mg/day initially) brought him marked improvement of the symptoms and laboratory data derived from PM. The cases in association with both PBC and PM have been rarely reported. Those literaures are reviewed. Such cases may be present more latently without correct diagnosis. It is important to pay attention to myositic manifestations in PBC patients for early detection of PM association.